Endocrine Abstracts

Introduction: Acute pancreatitis induced by hypertriglyceridemia is a severe condition and its management is complicated.Case report: We present a case of severe acute pancreatitis induced by hypertriglyceridemia secondary to lipoprotein lipase -LPL- deficiency (188 Gly-Glu mutation, LPL undetectable activity) in a pregnant patient with gestational diabetes.The patient was sent to our Lipid Unit in the 13th gestation’ week. Th...

Introduction: There is a reduction of the incretin effect in patients with type 2 diabetes secondary to altered secretion of incretin hormones and/or failed of its action.Objective: To study the GLP-1 secretion pattern after an oral glucose tolerance test (OGTT) in postpartum reassessment of women with previous GDM.Materials and methods: Prospective epidemiological study of 48 women with a history of GDM. We evaluated age, history ...

Introduction: Amiodarone use may be associated with secondary severe organ dysfunction. Thyrotoxicosis develops in 15% cases. Primary bilateral adrenal lymphoma is a rare malignancy. If frequently presents bilaterally and with symptoms of adrenal insufficiency. Symptomatology for both conditions is nonspecific, especially in the elderly, and a high suspicion index is necessary for appropriate diagnosis.Case report: A 78 year old female presented to the e...

Introduction: Obesity is a chronic disease associated with multiple comorbidities, defined by BMI, without considering the metabolic state of the patient. There are few data on the proportion of obese patients without metabolic syndrome (MS).Objective: To characterize patients considered to be metabolically healthy (MH) followed at the obesity outpatient clinic of one University Hospital, and to compare this group with a group of obese patients with MS.<...

Introduction: The Nephron is a known target organ of the Growth Hormone/Insulin-like factor-1 axis. They influence glomerular and tubular function having an important physiological role in water and electrolyte balance, especially in Acromegaly. The aim of the study was to investigate renal function in acromegalic patients during active disease and remission and evaluate hormonal impact on renal function markers.Methods: A retrospective, longitudinal, ob...

Introduction: The prevalence of palpable nodules varies between 3–7% and nodules diagnosed by ultrasonography between 20–76%. According to the American Thyroid Association’s guidelines it isn’t recommended to perform routine thyroid ultrasound for thyroid nodules diagnosis, unless they are palpable or there are any risk factors.Objective: Evaluation of sonographic and cytological differences between palpable and non-palpable thyroid n...

Aim: To know if Tg levels after treatment (total thyroidectomy and radioiodine ablation) in the DTC can predict their prognosis in the long term.Material and methods: Basal Tg and Tg after rh-TSH were measured in 229 patients with DTC without any evidence of residual tumour (negative neck ultrasonography) after treatment. The group was followed until tumour recurrence or, if recurrence was not found, a minimum of 12 month (mean ± SD =63±37 mont...

Introduction: Our objective is to determine the profile of patients with differentiated thyroid cancer (DTC) attended in our center and the therapeutic approach employed.Methods: Retrospective review of medical records from patients treated for DTC during the years 2013 and 2014.Results: Data from 387 patients, 84% female, 96% Caucasian, mean follow up of 10.82 years. The average age at diagnosis was 44.24 years, 77% had normal thy...

Introduction: Cushing’s disease (CD) is a rare disorder caused by an ACTH-secreting pituitary adenoma. Transsphenoidal surgery (TSS) is the recommended first-line treatment. However, an equivocal or even normal preoperative MRI can preclude the surgical management and the outcome of these patients.Objectives: Evaluate the relationship between preoperative MRI and TSS efficacy in patients with CD.Methods: Retrospective cohort s...

Objective: Cushing’s disease (CD) is caused by pituitary corticotrophin (ACTH)-secreting tumours. Our aim is to show our experience in a third level hospital attending a 500 000 based population area from 1990 to now.Methods: We review retrospectively the medical reports of all patients diagnosed as CD from 1990 by a data collection protocol. We reject the reports without enough or inadequate information. We present results by using descriptive stat...